Our studies

A therapeutic particularity recognized since 1983


The sulphated water, both with calcium and magnesium, of Castéra-Verduzan benefits from an anti-plaque, analgesic, antibacterial and healing action for the oral mucosa. This effectiveness has been scientifically demonstrated by more than 200 research studies.

We place at your disposal below relevant studies which prove the effectiveness of this exceptional water, the main ingredient of the products in our range:


  • An anti-plaque action

BUCCOTHERM, anti-plaque action graphic

The mineral-thermal water of Castéra-Verduzan. Experimental in vivo study carried out by Dr. B. SEGUIN. Thesis, dental surgeon, Bordeaux II, 1984.

The therapeutic effect of the Thermal Spring water has been measured on gingivitis created by the lack of oral hygiene, i.e. without tooth brushing.
At the end of the cure, we note that the subjects have healthier gums and improve their DI (Debris Index) from the 9th day of their cure, which proves the anti-plaque action of the Thermal water of Castéra-Verduzan.


  • An analgesic action

BUCCOTHERM, Analgesic action graphic

Summary clinical evaluation of the analgesic and healing effects of BUCCOTHERM® Sensitive Gums and Dental Spray. Study by Dr. Lesclous, MCU – PH. Faculty of Dental Surgery René Descartes University Paris V, July 2005.

The intensity of the pain 5min before and after the use of the product is reduced by half from the first 2 days.
BUCCOTHERM® Sensitive Gums, alone or combined with the Dental Spray, shows a significant analgesic action on common mouth ulcers.
The duration of the analgesic action is 5 hours. No adverse effects have been recorded.
The average duration of treatment until complete healing is 5.2 days compared to 7 to 10 days without treatment.


  • An antibacterial action

BUCCOTHERM, Antibacterial action graphic

In vitro bacteriological evaluation, comparative, versus placebo.
Study by Dr. M. Sixou, PhD, PCU-PH, Faculty of Dental Surgery of Toulouse, 2005.

This study clearly demonstrates that BUCCOTHERM® Dental Spray respects the supra-gingival oral ecosystem and has no antibacterial activity on the main Gram-positive aero-anaerobic bacteria in the oral sphere. This result suggests that this product can be used over the long term without negative impact on oral ecology.
A moderate antibacterial action (lower than a reference antiseptic such as chlorhexidine 0,12%) was demonstrated on the five principal peri-pathogens making it possible to let think, if complementary studies confirmed it, that this product would be indicated in a complement to the periodontal treatments within the framework of the periodontal diseases.


  • An action on gingival bleeding

BUCCOTHERM, gingival bleeding action graphic

Evaluation of the efficacy of BUCCOTHERM® products on the reduction of gingival bleeding: randomized pilot trial.
Study by Dr. M. Sixou, Dr. M. Vergnes, July 20, 2010

In general, regarding patients with gingivitis, there is a decrease in the extent and severity of gingivitis in an adult population after prescription of oral hygiene products, starting at 3 weeks. The effect is maintained for 2 months.
This observation is more marked for patients treated with BUCCOTHERM® products: the inflammation will have decreased more than that of the control group, after 3 weeks, with an effect maintained for 2 months.


Our Research and Development department is the keystone of our offer and this is why we make it a point of honor to be in permanent contact with the scientific world: university and hospital laboratories, experts in biotechnologies, bioengineering or clinical research.

All BUCCOTHERM® products are developed in collaboration with dentists and pharmacists. Each product meets the rigorous standards of the pharmaceutical industry to ensure optimal action with maximum tolerance. The claims indicated on the products have been demonstrated by clinical or objectivation tests under the supervision of dentists.